Pantelis R. Vlachas


Principal Machine Learning Scientist, Liom Health / Affiliated Researcher, ETH Zurich

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Hi!

I’m Pantelis R. Vlachas, a Principal Machine Learning Scientist at Liom Health, where I work on machine learning for non-invasive health monitoring.

I am affiliated with ETH Zurich, where I work on generative modeling for spatial transcriptomics with Kalin Nonchev at Gunnar Rätsch’s Biomedical Informatics group.

At the same time, I am affiliated with the group of Prof. Eleni Chatzi, where I am exploring hypernetworks, inverse problems, parametric modeling and adaptive surrogate models of dynamical systems with online and real-time learning capabilities.

More broadly, my research lies at the intersection of machine learning, dynamical systems, and (lately) biology. It explores how ML methods enable the prediction of complex dynamics, inference of hidden properties, and discovery of underlying structure in systems ranging from turbulent flows to biological processes. Current focus areas include deep learning, probabilistic modeling, and scientific machine learning, with an emphasis on models that generalize to unseen regimes and adapt online.

Before that, I was leading the ML Research team at AI2C Technologies for four years, a spin-off from ETH working on novel machine learning solutions for fintech.

I completed my Ph.D. under the supervision of Prof. Petros Koumoutsakos in the CSE Lab in Zurich. There I worked on novel efficient methods for learning effective dynamics of complex systems. We demonstrated the effectiveness of the developed methods in a wide range of applications, from systems that exhibit spatiotemporal chaotic behavior and turbulent flows to small molecules. During my Ph.D. I also visited the John A. Paulson School Of Engineering And Applied Sciences in Harvard as an Associate Researcher.

I am always open to chat about cool projects, ideas, and collaborations.

News

November 4, 2026 From November 16, 2026, I am joining Liom Health as Principal Machine Learning Scientist, working on machine learning for non-invasive health monitoring.
September 22, 2026 I gave an online talk at the Fifth International Nonlinear Dynamics Conference (NODYCON 2026), hosted by Sapienza University of Rome, on September 22, 2026. The talk, Weight-Space Interpolation for Parametric Dynamical Systems via Hypernetworks with Learned Embeddings, joint work with Konstantinos Vlachas and Eleni Chatzi, presented PHLieNets, published in MSSP, and how a single hypernetwork model forecasts across an entire parametric family of nonlinear dynamical systems.
July 8, 2026 Our paper Beyond Static Models: Hypernetworks for Adaptive and Generalizable Forecasting in Complex Parametric Dynamical Systems, with Konstantinos Vlachas and Eleni Chatzi, is now published open access in Mechanical Systems and Signal Processing (Volume 258, 2026). A preprint is on arXiv. The paper introduces PHLieNets, hypernetworks that learn an embedding of the system parameters and generate the weights of a forecasting network, so that a single model covers an entire family of parametric dynamical systems and generalizes to regimes unseen during training.
June 8, 2026 Our paper Transcriptomics-Conditioned Virtual Tissue Synthesis via Diffusion Transformers has been accepted at the ICML 2026 Workshop on Structured Data for Health (SD4H) at ICML 2026. The work, in collaboration with Kalin Nonchev, Viktor Koelzer, and Gunnar Rätsch, introduces a diffusion-transformer framework that conditions on transcriptomics to synthesize high-resolution virtual tissue, bridging spatial omics and computational pathology.
October 1, 2025 I will be giving a talk on PHLieNets at the joint 5th Symposium on Machine Learning and Dynamical Systems (MLDS 5) and Differential Equations for Data Science (DEDS 2026). The event will take place at the Research Institute for Mathematical Sciences (RIMS), Kyoto University, from February 9–13, 2026. This symposium brings together researchers at the intersection of machine learning, dynamical systems, and mathematical modeling, an ideal venue to discuss how PHLieNets can enable scalable and generalizable learning across parametric dynamical systems.